柯俊良教授的靈芝研究論著

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中山醫學大學柯俊良教授研究靈芝免疫調節蛋白近二十年,主要在探討以下幾個主題:(一) 抗過敏、抗發炎與免疫調節作用;(二) 抑制非小細胞肺癌的生長、轉移的能力與機制;(三) 對化療藥的輔助作用,包括減輕副作用、提升療效、降低癌細胞的抗藥性等。

整理/吳亭瑤

 

期刊論文

1. Hsin IL, Wang SC, Li JR, Ciou TC, Wu CH, Wu HM, Ko JL. 2016.Hsin IL, et al. Immunomodulatory proteins FIP-gts and chloroquine induce caspase-independent cell death via autophagy for resensitizing cisplatin-resistant urothelial cancer cells. Phytomedicine. Available online 10 September. doi: 10.1016/j.phymed.2016.09.003.

2. Ou CC, Hsiao YM, Hou TY, Wu MF, Ko JL. 2015. Fungal immunomodulatory proteins alleviate docetaxel-induced adverse effects. Journal of Functional Foods. 2015 Sep; 19: 451-463.

3. Chiu LY, Hu ME, Yang TY, Hsin IL, Ko JL, Tsai KJ, Sheu GT. 2015. Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells. PLoS One. 10(5): e0125774. doi: 10.1371/journal.pone.0125774. eCollection 2015.

4. Hsin IL, Ou CC, Wu MF, Jan MS, Hsiao YM, Lin CH, Ko JL. 2015. GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells. Mol Pharm. 12(5):1534-43. doi: 10.1021/mp500840z.

5. LI JR, CHENG CL, YANG WJ, YANG CR, OU YC, WU MJ, KO JL. 2014. FIP-gts potentiate autophagic cell death against cisplatin-resistant urothelial cancer cells. Anticancer Res. 34(6):2973-83.

6. Li JR, Cheng CL, Yang WJ, Yang CR, Ou YC, Wu MJ, Ko JL. 2014. FIP-gts potentiate autophagic cell death against cisplatin-resistant urothelial cancer cells. Anticancer Res. 34(6):2973-83.

7. Wu TY, Chen HA, Li FY, Lin CT, Wu CM, Hsieh FC, Tzen JT, Hsieh SK, Ko JL, Jinn TR. 2013. High-level expression, purification and production of the fungal immunomodulatory protein-gts in baculovirus-infected insect larva. Appl Biochem Biotechnol. 169(3):976-89. doi: 10.1007/s12010-012-0049-2.

8. Hsin IL, Sheu GT, Jan MS, Sun HL, Wu TC, Chiu LY, Lue KH, Ko JL. 2012. Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein from Ganoderma microsporum. Br J Pharmacol.167(6):1287-300. doi: 10.1111/j.1476-5381.2012.02073.x.

9. Hsin IL, Ou CC, Wu TC, Jan MS, Wu MF, Chiu LY, Lue KH, Ko JL. 2011. GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells. Autophagy.7(8):873-82.

10. Lin CH, Hsiao YM, Ou CC, Lin YW, Chiu YL, Lue KH, Chang JG, Ko JL. 2010. GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells. J Agric Food Chem. 58(22):12014-21. doi: 10.1021/jf103068w. Epub 2010 Oct 28. 

11. Liao CH, Hsiao YM, Lin CH, Yeh CS, Wang JC, Ni CH, Hsu CP, Ko JL. 2008. Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae. Food Chem Toxicol. 46(5):1851-9. doi: 10.1016/j.fct.2008.01.044.  

12. Wang PH, Yang SF, Chen GD, Han CP, Chen SC, Lin LY, Ko JL. 2007. Human nonmetastatic clone 23 type 1 gene suppresses migration of cervical cancer cells and enhances the migration inhibition of fungal immunomodulatory protein from Ganoderma tsugae. Reprod Sci.14(5):475-85.

13. Liao CH, Hsiao YM, Sheu GT, Chang JT, Wang PH, Wu MF, Shieh GJ, Hsu CP, Ko JL. 2007. Nuclear translocation of telomerase reverse transcriptase and calcium signaling in repression of telomerase activity in human lung cancer cells by fungal immunomodulatory protein from Ganoderma tsugae. Biochem Pharmacol. 74(10):1541-54.  

14.Jinn TR, Wu CM, Tu WC, Ko JL, Tzen JT. 2006. Functional expression of FIP-gts, a fungal immunomodulatory protein from Ganoderma tsugae in Sf21 insect cells. Biosci Biotechnol Biochem. 70(11):2627-34.

15. Liao CH, Hsiao YM, Hsu CP, Lin MY, Wang JC, Huang YL, Ko JL. 2006. Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. Mol Carcinog. 45(4):220-9.

 

指導與靈芝相關之碩、博士論文

1. 許人婕,2016,探討靈芝免疫調節蛋白抑制肺癌細胞之Wnt/β-catenin訊息傳遞路徑,中山醫學大學醫學研究所碩士論文。

2. 邱彩醇,2015,靈芝免疫調節蛋白與氯奎寧經由細胞自體吞噬和非依賴型劊蛋白路徑誘發鉑金抗藥性泌尿道上皮癌細胞死亡之機制,中山醫學大學醫學研究所碩士論文。

3. 李建儀,2014,透過細胞自噬作用可有效克服cisplatin抗藥性之泌尿道移行上皮細胞癌的化療抗性,中山醫學大學醫學分子毒理學研究所博士論文。

4. 侯婷譯,2014,探討真菌類免疫調節蛋白質改善歐洲紫杉醇引起的不良副作用,中山醫學大學醫學研究所碩士論文。

5. 辛翌綸,2012,靈芝免疫調節蛋白誘發肺癌細胞自體吞噬與輔助療法應用之機制探討,中山醫學大學醫學研究所博士論文。

6. 廖建皇,2008,靈芝免疫調節蛋白抑制肺癌細胞端粒酶活性其相關分子機制之探討,中山醫學大學醫學分子毒理學研究所博士論文。

7. 胡哲榮,2006,研究真菌類免疫調節蛋之免疫調節活性,中山醫學大學醫學分子毒理學研究所碩士論文。

8. 倪嘉鴻,2005,探討松杉靈芝免疫調節功能蛋白抑制肺癌A549細胞株之轉移能力及其機制,中山醫學大學醫學分子毒理學研究所碩士論文。

9. 王文賢,2005,真菌類免疫調節功能蛋白抗發炎及穩定性之研究,中山醫學大學醫學分子毒理學研究所碩士論文。

10. 王宗煥,2004,1.研究p53基因受干擾的A549肺癌細胞株對化療藥cisplatin之影響2.研究松杉靈芝免疫調節功能蛋白抑制肺癌A549細胞株之生長及移行性,中山醫學大學毒理學研究所碩士論文。

11. 黃玉儒,2003,靈芝免疫調節蛋白的作用機制及其減緩塵蟎致敏之應用,中山醫學大學毒理學研究所碩士論文。

Ko-JL-2

2012年夏末秋初,柯俊良與學生合影。(攝影/楊文卿)